Claudio Santambrogio has been active as a flutist both in the field of early as well as contemporary music, specializing on period instruments. He is a member of the ensemble 'de vinea', specialized in Medieval Music, and of The Modena Consort, a quartet of Renaissance transverse flutes.

He has conducted extensive research on iconographical and textual references of the transverse flute in the Middle Ages, and has explored the repertoire of what he believes being a forgotten golden age of the transverse flute, the late 14th century culminating in the so-called Ars subtilior.

With Boaz Berney he worked on the reconstruction of an instrument for this repertoire, based on a very unusual instrument from the Musikinstrumentemeuseum in Berlin.